Ling Li, Ph.D.
Research Associate
Lab Manager

Email: ling.li@mcgill.ca

Tel: 514-398-6355

Background:

Experienced Clinical and Research Professional with an excellent background in Medicine and Biomedical Sciences.

Research Expertise:

  • molecular biology

  • cell biology

  • animal surgery and transgenic animal models

  • clinical research

Favourite Lab Equipment:

Fluorescence Microscope and Dissection Microscope

Research Interests:

Research interests include the translation of biomedical research discoveries into improved clinical care

  • Ph.D. Student Prize of Excellence (5000$), Foundation of J.A. De Sève Award, Université de Montréal (2004)

    Ph.D. Student Prize of Excellence (3000$), CHUM Research Centre, Notre-Dame Hospital (2003)

    Ph.D. Student Prize of Excellence (3000$), Biomedical Sciences Department, Université de Montréal (2002)

    Ph.D. Student Prize of Excellence (3600$), Association Diabète Québec (2002)

    Young Investigator Award (500$), Canadian Atherosclerosis Society (2001)

    Master Student Prize of Excellence (2000$), Biomedical Sciences Department, Université de Montréal (2000)

    Scholarship for International Ph.D. Student (12000$), Éducation du Québec (2002-2004)

    Scholarship for International Master Student (12000$), Education du Québec (1999-2001)

    Honor of Winning Participant, 5th annual Pharmacology Research Day in Merck Frosst Inc (2005)

  • Peer-Reviewed Articles:

    Sun B, Tomita B, Salinger A, Tilvawala RR, Li L, Hakami H, Liu T, Tsoyi K, Rosas IO, Reinhardt DP, Thompson PR, Ho IC. PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis. Matrix Biology 2021, 00: 1-15.

    Davis EC and Li L. Histological and electron microscope staining for the identification of elastic fiber networks. Methods Mol Biol 2017, 1627:385-393.

    Habibzadeh S, Li L, Omanovic S, Shum-Tim D, Davis EC. Biocompatibility of Ir/Ti-oxide coatings: Interaction with platelets, endothelial and smooth muscle cells. Applied Surface Science 2014, 301: 530-538.

    Habibzadeh S, Li L, Shum-Tim D, Davis EC, Omanovic S. Electrochemical polishing as a 316L stainless steel surface treatment method: Towards the improvement of biocompatibility. Corrosion Science 2014, 87:89-100.

    Harvey J, Bergdahl A, Dadafarin H, Li L, Davis EC, Omanovic S. An electrochemical method for functionalization of a 316L stainless steel surface being used as a stent in coronary surgery: irreversible immobilization of fibronectin for the enhancement of endothelial cell attachment. Biotechnol Lett 2012,34:1159-1165.

    Mugabo Y, Li L, Renier G. The connection between C-reactive protein (CRP) and diabetic vasculopathy. Focus on preclinical findings. Curr Diabetes Rev 2010,6:27-34.

    Li L, Renier G. The oral anti-diabetic agent, gliclazide, inhibits oxidized LDL-mediated LOX-1 expression, metalloproteinase-9 secretion and apoptosis in human aortic endothelial cells. Atheroslcerosis 2009,204:40-46.

    Maingrette F, Li L, Renier G. Creactive protein enhances macrophage lipoprotein lipase expression. J Lipid Res 2008, 49:1926-1935.

    Li L, Renier G. Lipoprotein lipase, an adipocyte-derived paracrine mediator of macrophage activation and monocyte recruitment in the obese adipose tissue. Obesity (Silver Spring) 2007,15:2595-2604.

    Renier G, Maingrette F, Li L. Diabetic vasculopathy and the lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1). Current Diabetes Reviews 2007,3:103-110.

    Li L, Renier G. Activation of nicotinamide adenine dinucleotide phosphate (reduced form) oxidase by advanced glycation end products links oxidative stress to altered retinal vascular endothelial growth factor expression. Metabolism 2006,55:1516-1523.

    Serri O, Li L, Mamputu JC, Beauchamp MC, Maingrette F, Renier G. The influences of hyperprolactinemia and obesity on cardiovascular risk markers: effects of cabergoline therapy. Clinical Endocrinology 2006,64:366-370.

    Mamputu JC, Li L, Renier G. Modulatory effect of gliclazide on human monocyte-derived macrophage function in vitro. Metabolism 2006,55:778-785.

    Renier G, MD, PhD, Mamputu JC, PhD, and Li L MD, PhD. PKC, Oxidative Stress and Retinal Endothelial Cell Dysfunction. The inhibitory effect of gliclazide on AGE-induced retinal endothelial cell dysfunction is out lined. Diabetic Microvascular Complications Today 2006 January/February.

    Li L, Mamputu JC, Wiernsperger N, Renier G. Signaling pathways involved in human vascular smooth muscle cell proliferation and matrix metalloproteinase-2 (MMP-2) expression induced by leptin. Inhibitory effect of metformin. Diabetes 2005,54:2227-2234.

    Li L, Roumeliotis N, Sawamura T, Renier G. C-reactive protein enhances lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) expression in human aortic endothelial cells. Relevance of LOX-1 to CRP-induced endothelial dysfunction. Circulation Research 2004,95:877-883.

    Li L, Sawamura T, Renier G. Glucose enhances macrophage LOX-1 expression. Role for LOX-1 in glucose-induced macrophage foam cell formation. Circulation Research 2004,94:892-901.

    Beauchamp MC, Michaud SE, Li L, Sartippour MR, Renier G. Advanced glycation end-products potentiate the stimulatory effect of glucose on macrophage lipoprotein lipase expression: Involvement of protein kinase C and mitogen-activated protein kinase. Journal of Lipid Research 2004,45:1749-1757.

    Li L, Sawamura T, Renier G. Glucose enhances LOX-1 expression in human endothelial cells: Role for LOX-1 in glucose-induced monocyte adhesion to endothelium. Diabetes 2003,52:1843-1850.

    Serri O, Li L, Maingrette F, Jaffry N, Renier G. Enhanced lipoprotein lipase secretion by macrophages of patients with growth hormone deficiency: Possible contribution to increased risk of atherosclerosis. Journal of Clinical Endocrinology & Metabolism 2003,89:979-985.

    Li L, Beauchamp MC, Renier G. Peroxisome proliferator-activated receptor alpha and gamma agonists upregulate human macrophage lipoprotein lipase expression. Atherosclerosis 2002,165:101-110.

    Book Chapters:

    Renier G, Li L, Roumeliotis N, Maingrette F. Role of metabolic and inflammatory factors in the regulation of vascular lectin-like oxidized low-density lipoprotein (LOX-1) expression: Relevance to diabetic vasculopathy. Research Advances in Lipids 2, 2006.

  • Oral Presentation

    Li L, Renier G. C-reactive protein expression in human monocytes/macrophages and endothelial cells: regulation by inflammatory cytokines and metabolic factors relevant to type 2 diabetes. 43th Annual Meeting of the European Association for the Study of Diabetes (EASD). September 16-21, 2007, Amsterdam, Netherlands.

    Li L, Renier G. Lipoprotein lipase, an adipocyte-derived paracrine mediator of macrophage activation and recruitment in the obese adipose tissue? The XIVth International Symposium On Atherosclerosis, June 18-22, 2006, Rome, Italy.

    Li L, Renier G. Role of adipose tissue lipoprotein lipase (LPL) in obesity-related inflammation. 8ième Congrès annuel des étudiants, stagiaires, et résidents du Centre de recherche du CHUM. December 20, 2005, Montreal, Quebec, Canada

    Li L. Regulation of lectin-like oxidized low-density lipoprotein receptor-1(LOX-1). Relevance to diabetic vasculopathy. Merck Frosst Pharmacology Research Day. October 28, 2005, Montreal, Quebec, Canada.

    Li L, Renier G. Signaling pathways involved in human vascular smooth muscle cell proliferation and matrix metalloproteinase-2 expression induced by leptin. Inhibitory effect of metformin. 41th Annual Meeting of the European Association for the Study of Diabetes (EASD). September 10-15, 2005, Athens, Greece.

    Li L, Roumeliotis N, Sawamura T, Renier G. C-reactive protein enhances lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) expression in human aortic endothelial cells. Relevance of LOX-1 to CRP-induced endothelial dysfunction. 40th Annual Meeting of the European Association for the Study of Diabetes (EASD). September 5-9, 2004, Munich, Germany.

    Li L, Sawamura T, Renier G. Glucose enhances macrophage LOX-1 expression. Role for LOX-1 in glucose-induced macrophage foam cell formation. 6ième Congrès annuel des étudiants, stagiaires, et résidents du Centre de recherche du CHUM. December 18, 2003, Montreal, Quebec, Canada.

    Li L, Renier G. Effect of high glucose on lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) gene expression in macrophages and endothelial cells. IIIe Congrès des stagiaires de recherche de la Faculté de médecine et des centres hospitaliers de l’Université de Montréal, January 26, 2003, Montreal, Quebec, Canada.

    Poster Presentation

    Li L, Renier G. Effect of high glucose on lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) gene expression in macrophages and endothelial cells. Association Diabète Québec, November 8-10, 2002, Quebec city, Canada.

    Li L, Renier G. Effect of high glucose on lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) gene expression in macrophages. Congès de la Société québécoise de lipidologie, de nutrition et de métabolisme, April 19-21, 2002, Bromont, Quebec, Canada.

    Li L, Renier G. Peroxisome proliferator-activated receptor agonists upregulate human macrophage lipoprotein lipase expression and secretion. Canadian Cardiovascular Congress, October 21-24, 2001, Halifax, NovaScotia, Canada.

    Li L, Renier G. Peroxisome proliferator-activated receptor agonists upregulate human macrophage lipoprotein lipase expression and secretion. IIIe congrès des stagiaires de recherch en santé de la faculté de médicine et des centres hopitaliers de l’Université de Montréal, January 27, 2001, Montreal, Quebec, Canada.

    Li L, Renier G. Peroxisome proliferator-activated receptor alpha upregulate human macrophage lipoprotein lipase expression and secretion. IIIe congrès annuel des étudiants, stagiaires, et résidents du Centre de recherche du CHUM, Hôpital Notre-Dame, December 20, 2000, Montreal, Quebec, Canada.

    Li L, Renier G. Peroxisome proliferator-activated receptor alpha upregulate human macrophage lipoprotein lipase expression and secretion. The XIIth International Symposium On Atherosclerosis, June 25-29, 2000, Stockholm, Sweden.