Laís Landim, Ph.D., D.M.D.
Postdoctoral Fellow

Department of Biomedical Engineering

Email: lais.landimgomes@mcgill.ca

LinkedIn | ORCID

Educational Background:

Ph.D in Restorative Dentistry – Prosthodontics and Dental Materials. São Paulo State University (UNESP), São José dos Campos, São Paulo, Brazil (2022)

Master in Restorative Dentistry – Endodontics. São Paulo State University (UNESP), São José dos Campos, São Paulo, Brazil (2018)

Specialist in Endodontics - Clinical Residency. The University of São Paulo (USP), Bauru, São Paulo, Brazil (2018)

Bachelor in Dental Surgery. São Paulo State University (UNESP), São José dos Campos, São Paulo, Brazil (2016)

Technician in Clinical Pathology. Vale do Paraíba University (UNIVAP)- São José dos Campos, São Paulo, Brazil (2011)

Favourite Lab Equipment:

Scanning Electron Microscope

Research Interests:

BIOLOGICAL PROPERTIES OF AN IN VITRO RECELLULARIZATION SEEDING HUMAN VASCULAR SMOOTH MUSCLE CELLS (HVSMCs) IN A DECELLULARIZED EXTRACELLULAR MATRIX (dECM) AS A BIOSCAFFOLD FOR AORTIC GRAFT

My research project is the development of a new decellularized extracellular matrix (dECM) as a scaffold for aortic graft. The search for biomaterials that mimic native cell functions is the biggest challenge within tissue regeneration research.The current aortic grafts present a mechanical mismatch with the native tissue, which brings negative consequences on organ perfusion, and therefore complications in the rehabilitation and treatment of the patients. Thereby, biomimetic and mechanically compatible grafts for aortic repair are urgently needed to bring more conservative treatment possibilities that improve tissue repair and the longevity of the grafts, and as a result, improve the quality of the rehabilitation treatments performed on patients.

The development of this research can bring new perspectives in the field of tissue regeneration focused on aortic repair, enabling the advancement of treatments for patients, which motivates me to search for new approaches.

  • Capes Doctorate Ph.D Fellowship (23/02/2020– 01/03/2021) Fellowship provided by the Brazilian Coordination of Superior Level Staff Improvement (Capes).

    Capes Master’s Fellowship (13/01/2017 – 17/12/2018) Fellowship provided by the Brazilian Coordination of Superior Level Staff Improvement (Capes.)

    FAPESP- Undergraduate Scholarship (01/02/2016 – 01/02/2017) (Grant 2015/23324-1). Scholarship provided by the São Paulo State Research Support Foundation for conducting undergraduate scientific research.

    1st place in the Brazilian Dental Materials Group conference in São Paulo Brazil (2023).
    Undergraduate research category
    Research: Influence of a new fiber optic photopolymerization system on printed intraradicular post cementation. Souza MF, Silva JFG, Gomes LCL, Paes Junior TJA.
    Advisor: Prof. Dr. Tarcísio José de Arruda Paes Junior

    2nd place in the Brazilian Dental Materials Group conference in São Paulo Brazil (2023).
    Graduate and professional research category
    Research: Influence of a new light curing device with optical fiber and an experimental glass fiber post on the physicochemical, mechanical properties and adhesion of resin cement. Gomes LCL, Nakano LJN, Carvalho PCK, Siqueira L, Paes Junior TJA.
    Advisor: Prof. Dr. Tarcísio José de Arruda Paes Junior

    Honorable mention at the XXXV Scientific Initiation Conference of São Paulo State University, Regional level (2023)
    Research: Biological and chemical evaluation of a new fiber optic illuminating device and perforated fiberglass post in resin cements. Lupp JS, Gomes LCL, Silva LAA, Siqueira L, , Paes Junior TJA, Vasconcellos LMR.

    2nd place at the XXXV Scientific Initiation Conference of São Paulo State University, Provincial level (2023)
    Research: Biological and chemical evaluation of a new fiber optic illuminating device and perforated fiberglass post in resin cements. Lupp JS, Gomes LCL, Silva LAA, Siqueira L, , Paes Junior TJA, Vasconcellos LMR.

    1st place – National case writing competition and a presenter at the Aldo Papone International Student Teacher Conference, Nice, France (2008).

  • Peer-Reviewed Articles:

    Pierre FZ, Gomes LCL, Minhoto GB, Valera MC, de Melo RM, Bresciani E. Influence of the Use of Irrigation Solution Inhibitors in Improving Dentine Adhesion: A Systematic Review and Meta-Analysis. Eur J Prosthodont Restor Dent. 2023 Jul 18. doi: 10.1922/EJPRD_2526Pierre17. Epub ahead of print. PMID: 37463022.

    Arcila LVC, Gomes LCL*, Travassos A, Fernandes VVB, Nascimento RD, Ursi W, et al. Multidisciplinary action in a patient with cleft lip and palate: esthetic-functional dentofacial treatment for more than two decades. Braz Dent Sci. 2023;26(2):e3801. https://doi.org/10.4322/bds.2023.e3801

    Arcila LVC, Gomes LCL*, Ortiz LPN, Costa MMD, Tribst JPM, Bottino MA, Saavedra GSFA, de Melo RM. Effect of Resin Cement at Different Thicknesses on the Fatigue Shear Bond Strength to Leucite Ceramic. Eur J Dent. 2022 Dec 19. doi: 10.1055/s-0042-1758797. Epub ahead of print. PMID: 36535658

    Fernanda Z. Pierre, Laís Carolina L. Gomes*, Giovanna B. Minhoto, Marcia C. Valera, Renata M. de Melo and Eduardo Bresciani. Influence of the use of irrigation solution inhibitors in improving dentine adhesion: A Systematic Review and Meta-Analysis. European Journal of Prosthodontics and Restorative Dentistry. Accepted date: June 19, 2023

    Gomes, L.C.L.; Pierre, F.Z.; Tribst, J.P.M.; Ramos, N.d.C.; Bresciani, E.; de Araújo, R.M.; Júnior, L.N.; Bottino, M.A. Occlusal Scheme Effect on the Biomechanical Response of Full-Arch Dental Prosthesis Supported by Titanium Implants: A Systematic Review. Metals 2021, 11, 1574. https://doi.org/10.3390/met11101574

    Nakano, L.J.N.; Gomes, L.C.L.; de Queiroz, T.S.; Paes-Junior, T.J.d.A. Effect of Abutment Type and Tightening Sequence on Torque Maintenance Capacity after Mechanical Cycling in Splinted Implant-Supported Restorations. Oral 2021, 1, 300-306. https://doi.org/10.3390/oral1040029

    Burim R. A. Gomes L. C. L, Gomes, M. S. S, Rossi, N. R, Nakano, L. J. N, Paes Júnior, T. J. A. Tratamento por prótese total imediata devido a insucesso na utilização de implantes osseointegrados. Implant News International Journal, 2021.

    Landim Gomes, L. and Dutra, J.C. 2021. Endodontic surgery: a review of postoperative and healing outcome. journal of surgical and clinical research. 12, 1 (Dec. 2021), 24–39 https://doi.org/10.20398/jscr.v12i1.24054

    Camargo CHR, Gomes LCL, França MCM, Bittencourt TS, Valera MC, Camargo SEA, Bottino MC. Incorporating N-acetylcysteine and tricalcium phosphate into epoxy resin-based sealer improved its biocompatibility and adhesiveness to radicular dentine. Dent Mater. 2019 Dec;35(12):1750-1756. doi: 10.1016/j.dental.2019.09.001

    Patents:

    Novel light curing emitting device -Brazilian National Institute of Industrial Property - INPI in 2020 BR 10 2020 025592 4.

    Experimental fiberglass post, Brazilian National Institute of Industrial Property - INPI in 2020 (BR 10 2020 020331 2 )

  • Conferences:

    Gomes LCL*, Nakano LJN, Carvalho PCK, Siqueira L, Paes Junior TJA. Influence of a new light curing device with optical fiber and an experimental glass fiber post on the physicochemical, mechanical properties and adhesion of resin cement. Brazilian Dental Materials Group conference in São Paulo, Brazil (2023).

    Souza MF, Silva JFG, Gomes LCL*, Paes Junior TJA. Influence of a new fiber optic photopolymerization system on printed intraradicular post cementation. Brazilian Dental Materials Group conference in São Paulo, Brazil (2023).

    GOMES, L.C.L*; Arcila LVC; Ortiz LN; Mardoqueu M. da Costa; Tribst JPM; Bottino MA; Saavedra GSFA; Melo RM. Effect of resin cement at different thicknesses on the fatigue shear bond strength to leucite ceramic. 2021. 38th SBPqO Virtual Annual Meeting.

    GOMES, L. C. L*.; Dias RBG; NAKANO, L. J. N. ; PAES JUNIOR, T. J. A. . Surface analysis in composites for characterization of artificial gingiva submitted to aging by brushing. 2020. SBPqO Annual Meeting. São Paulo (Online due to Covid pandemic).

    GOMES, L. C. L*.; Dias RBG; NAKANO, L. J. N. ; PAES JUNIOR, T. J. A. . Surface analysis in composites for characterization of artificial gingiva submitted to aging by brushing. 2020. 33° COB – FOB- USP, Bauru. (Online due to Covid pandemic).

    GOMES, L. C. L.*; Dias RBG ; NAKANO, L. J. N. ; PAES JUNIOR, T. J. A. . Surface analysis in composites for characterization of artificial gingiva submitted to aging by brushing. 2020. Brazilian Group of Dental Materials (GBMD) (Online due to Covid pandemic).

    SPIGARIOL, K. S; GOMES, L. C. L*. ; KHOURY, R. D. ; Carvalho, C.A.T ; CAMARGO, C. H. R. ; Valera, M.C* . Evaluation of apical extrusion and cytotoxicity of different solutions of sodium hypochlorite and dentin debris by spectrophotometry. 2019. SBPqO Annual Meeting. São Paulo.

    GAGLIARDI, C. F; GOMES, L. C. L.*; Valera, M.C; KHOURY, R. D. ; MINHOTO, G. B. . Evaluation of apical extrusion and cytotoxicity of different solutions of sodium hypochlorite and dentin debris by spectrophotometry 2019. CIC Scientific initiation Congress– UNESP.

    GOMES, L. C. L.*; CARDOSO, F. G. R.; TOIA, C. C.; OROZCO, E. I. F.; ROCCO, M. A. ; CARVALHO, C. A. T. ; Valera, M.C . Correlation between root canal volume and periapical lesion with bacteria in primary endodontic infections. 2018. SBPqO Annual Meeting. São Paulo.

    GOMES, L. C. L.*; Machado FP ; FRANCA, M. M. ; Camargo, S.E.A ; Valera, M.C ; CAMARGO, C. H. R. . Biological and adhesive properties of an endodontic sealer added with n-acetylcysteine and tricalcium phosphate. 2017. 30° COB – FOB- USP, Bauru.

    Machado FP; GOMES, L. C. L. *; FRANCA, M. M. ; Camargo, S.E.A ; Valera, M.C ; CAMARGO, C. H. R. . Effect of n-acetylcysteine on adhesion and cytotoxicity of endodontic sealers. 2017. 30° COB – FOB- USP, Bauru.

    GOMES, L. C. L*.; FRANÇA, MONIQUE COSTA MOREIRA ; Valera, M.C ; Machado FP ; Camargo, S.E.A ; CAMARGO, C. H. R. . Cytotoxicity, antimicrobial action and adhesiveness of ah plus sealer associated with n-acetylcysteine or tricalcium phosphate. 2017. SBPqO Annual Meeting. São Paulo

  • • Development of new biomaterials for tissue regeneration.

    • Drug delivery for Endodontic or Prosthodontics therapy.

    • Biocompatibility of new biomaterials used in dentistry.

    • Mechanical and adhesive behavior of biomaterials.

    During my postgraduate studies, I developed research methodologies in different dentistry fields, with mechanical, physical-chemical, and cell culture assays,

  • Teacher assistant (volunteer)

    Fixed Partial Denture Clinic of Dentistry undergraduate course at São Paulo State University (São José dos Campos) (2021-2022). I guided students in the clinic activities with patients’ treatments. Coordinator: Prof. Dr. Alberto Noriyuki Kojima & Prof. Dr. Osvaldo Daniel Andreatta.

    Fixed Partial Denture laboratory activities of Dentistry undergraduate course at São Paulo State University (São José dos Campos) (2020-2022). I guided students in the laboratory practical part of the Dentistry course. Coordinator: Prof. Dr. Alberto Noriyuki Kojima & Prof. Dr. Osvaldo Daniel Andreatta.

    Improvement and Support Program for Teaching in Higher Education – PAADES in Fixed Partial denture – Integrated Clinic of the Dentistry course at UNESP - ICT (2020-2022). Clinic and laboratory activities. treatments. Coordinator: Prof. Dr. Alberto Noriyuki Kojima & Prof. Dr. Osvaldo Daniel Andreatta.

    Endodontics Clinic of Dentistry undergraduate course at São Paulo State University (São José dos Campos). (2017-2018). I guided students in the clinic activities with patients’ treatments. Coordinator: Prof. Dr. Marcia Carneiro Valera, Prof. Dr. Cláudio Antonio Talge de Carvalho and Prof. Dr. Ana Paula Martins Gomes

    Endodontics laboratory activities of Dentistry undergraduate course at São Paulo State University (São José dos Campos) (2017-2018). I guided students in the lab practical part of the Dentistry course. Coordinator: Prof. Dr. Marcia Carneiro Valera, Prof. Dr. Cláudio Antonio Talge de Carvalho and Prof. Dr. Ana Paula Martins Gomes.

    University Extension Programs (volunteer)

    Oral rehabilitation with bone integrated implants – Prosthodontics Clinic in the Graduation Program. São Paulo State University (São José dos Campos) (2019-2022). Clinically working in prosthodontics treatment focus in the patients´ oral rehabilitations. Supervision: Prof. Dr. Lafayette Nogueira Junior.

    Academic Society Dentures Extension Project in Total dentures at São Paulo State university- (São José dos Campos) (2019-2021). Supervision: Prof. Dr. Tarcísio José de Arruda Paes Junior. I worked in the clinic on patients’ treatment for rehabilitation with total dentures.

    Extension program at Dental Trauma Center (CETRADE), São Paulo State University (São José dos Campos) (2017-2018). Clinically working in endodontics treatment and dental trauma emergency. Supervision: Profª.Dr. Marcia Carneiro Valera & Prof. Dr. Claudio Antonio Talge Carvalho.

    Editor assistant of Brazilian Dental Science Journal (BDS) – São Paulo State University, Institute of Science and Technology (2020- present).

    Reviewer of Journal of Advances in Medicine and Medical Research (2021- present).

    Reviewer of Implant news (2022-present).

    GRANTS: Capes Doctorate Ph.D Fellowship (23/02/2020– 01/03/2021) Fellowship provided by the Brazilian Coordination of Superior Level Staff Improvement (Capes) for the first year of doctorate degree program.

    Capes Master’s Fellowship (13/01/2017 – 17/12/2018) Fellowship provided by the Brazilian Coordination of Superior Level Staff Improvement (Capes) for the entire length of master’s degree program.

    FAPESP- Undergraduate Scholarship (01/02/2016 – 01/02/2017) (Grant 2015/23324-1). Scholarship provided by the São Paulo State Research Support Foundation for conducting undergraduate scientific research.

    Co-supervision of Bachelor’s students: Carolina França - Prosthodontics (2021-2022). Fernanda Bertoni - Endodontics (2017-2018). Worked as a Clinical Specialist Dentist - (2017-2023).