Ahlem Meziadi, Ph.D.
Postdoctoral Fellow

Department of Biomedical Engineering

Email: ahlem.meziadi@mcgill.ca

LinkedIn

Educational Background:

Ph.D. in Biomaterials Science and Biotechnology Institut national de la recherche scientifique (INRS). Varennes, QC, Canada (2023)

Master of science in Chemical Engineering Université libre de Tunis. Tunis, Tunisia (2016)

Bachelor of science in Fine Chemistry. Faculty of Science of Monastir. Monastir, Tunisia (2012)

Favourite Lab Equipment:

The shaker, which I also call "the belly dancer," is essential for making the spheroids with its rhythmic movements

In science, the first try rarely goes perfectly...it’s all part of the journey
— Ahlem Meziadi

Research Interests:

Advanced multilayer islet encapsulation incorporating cytotoxic T-lymphocyte associated protein 4 and zinc oxide nanoparticles for localized Immunomodulation

  • Award for best oral presentation; JScience-INRS (2022)

    Award for best poster presentation; CSPS/CC-CRS: Trainee Poster award (2021)

    FRQS fellowship, PhD research scholarship of the fond de recherché of Quebec (2020-2021)

    Fellowship from the NSERC CREATE Network Process Engineering (PrEEMIUM) of CRSNG (2019-2021)

    Mentor fellowship from INRS-EMT to support the integration of new master and PhD students (2021)

    Award of Excellence for Student Involvement -Ambassador (2019)

    Award of Excellence for Student Involvement -Ambassador (2020)

    Award for best oral presentation; University Libre de Tunis (2016)

  • Peer-Reviewed Articles:

    A. Meziadi1, A. Greschner, Marc A. Gauthier, Microwave induced transient heating to promote protein PEGylation. Biomacromolecules 2023, 24, 6, 2856-2863

    A. Meziadi, N. Zuberi, H W. de Haan, and Marc A. Gauthier, Overcoming PEG─ Protein Mutual Repulsion to Improve the Efficiency of PEGylation. Biomacromolecules 2022, 23, 11, 4948–4956

  • ORAL PRESENTATIONS

    1. Simultanuously cooled microwave reactor to promote bioconjugation reactions. Jsciences, Varennes, Canada, Virtual, February 2022. Awarded as best oral presentation

    2. Nanoscale manifestations of the excluded volume effect and overcoming its impact on protein PEGylation, Virtual, CBS 2021, Canada.

    3. Chemical and physical approaches to overcome the challenge of nano-phase separation in bio conjugation reactions.11th Summer School on Medicines Conference (SSM11), Faculty of pharmacy, Montreal, Canada, June 2019.

    4. Electromagnetic irradiation to overcome the nanoscale separation in bio conjugation, Competition my thesis in 3 minutes, INRS, Quebec City, Canada, March2019.

    5. Chemical and physical approaches to overcome the challenge of nano-phase separation in bioconjugation reactions. Institut national de recherche Scientifique INRS, Varennes, Canada December 2018.

    6. Bio conjugation reactions and their challenges. INRS, February 2017.

    7. Synthesis of a polymer with molecular fingerprints for the extraction of urinary 2,5-Hexanedione and optimization of analyses by GC-MS, Institute for Occupational Health and Safety in Tunisia (Collaborator of World Health Organization) 2016.

    8. Synthesis of a polymer with molecular fingerprints for the extraction of urinary 2,5-Hexanedione and optimization of analyses by GC-MS. Université libre de Tunis, Tunis, Tunisia, 2016. Awarded as best oral presentation

    9. Analytical validation of a dosage method of amoxicillin in Amoxal 500mg and optimization of the analyses by HPLC. Faculty of Sciences of Monastir, Tunis, Tunisia May 2012.

    POSTER PRESENTATIONS

    1. Ahlem Meziadi, Victoria Bloquert, Marc A. Gauthier: Molecular crowding effects on the enzymes of the glucose oxidase–horseradish peroxidase cascade reaction. CRS conference 2023, Las Vegas, Canada. Awarded as best poster presentation.

    2. Ahlem Meziadi, Andrea Greschner, Marc A. Gauthier: Microwave induced transient heating to promote protein PEGylation, CRS conference 2022, Montreal, Canada.

    3. Ahlem Meziadi, Marc A. Gauthier: Simultaneously cooled microwave reactor to promote bioconjugation reactions. CSPS/CC-CRS conference Mai 2021, Virtual. Awarded as best poster presentation.

    4. Ahlem Meziadi, Marc A. Gauthier: Effect of Excluded volume and electromagnetic radiation on bio conjugation reactions. CSPS/CC-CRS Conference 2017, Canada; May 2018

    5. Ahlem Meziadi, Marc A. Gauthier: Overcoming the challenge of nano-phase separation in bio-conjugation reactions. CBS conference 2019, Canada; May 2019

    6. Ahlem Meziadi, Marc A. Gauthier: The art of encapsulation, from the encapsulation of flavors in gels to the encapsulation of therapeutic agents in hydrogels, INRS-EMT, Varennes; September 2019

    7. Ahlem Meziadi, Rihab Jemli, Thana Saffar: Extraction and purification of prickly pear essential oil, Université Libre de Tunis (ULT), Tunis, Tunisia; October 2015

  • April 2023 - August 2023: Institution: Institut national de la recherche scientifique (INRS). Varennes, QC, Canada
    Role: Postdoctoral Fellow
    Supervisor: Prof. Marc André Gauthier
    Project: Creation of shape-changing bispecific aptamers that can mimic the therapeutic effects of BiTEs while incorporating IF/THEN logic (continuation of last project started in PhD).

    June 2022 - September 2022: Institut National de la recherche scientifique (INRS).Varennes, QC, Canada
    Role: Internship
    Supervisor: Luca Razzari
    Project: THz spectroscopy to study protein hydration in presence of polymers

    January 2019 - December 2021: PrEEmiuM Student Training. Montreal, QC, Canada
    Series of courses and workshops over 3 years during the PhD (15 credits in total) on pharmaceutical science, bioengineering and biotechnology

    February 2016 - June 2016: Institute of Occupational Health and Safety (Collaborator of WHO).Tunis, Tunisia
    Role: Internship
    Supervisor: Radouane Chakroune;
    Project: Synthesis of a molecular imprinted polymer (MIP) for the selective extraction of urinary 2,5 Hexanedione and optimization of the analyses by gas chromatography coupled with mass spectrometry (GC-MS)

    February 2012 - June 2012: Medicef « Groupe HIKMA »
    Role: Internship
    Supervisor: Ryme Tira
    Project: Analytical validation of dosage of amoxicillin in Amoxal 500mg Description: I developed an analytical method to validate the dosage of Amoxicillin, which is an antibiotic used to treat a number of bacterial infections, in Amoxal 500mg using HPLC and characterize its galenic formulation

    OTHER TRAININGS AND CERTIFICATIONS

    June 2019: 11th Summer school on Medicines, Drug discovery: from target to market, Faculty of pharmacy, Montreal, Canada; Description: 50-hour training program on drug discovery, development and market access; Benefits: An excellent introduction to drug discovery process from basic research of disease pathways to the rational design of safe and effective molecules.

    July 2015 - August 2015: “Responsible in Management QHSE” (Quality, Hygiene, Safety, Environment), International training solutions, Tunis, Tunisia;
    Description: An area of technical expertise that controls the aspects related to occupational risks within the company in order to lead to an integrated management system

    July 2015 - September 2016: Tunisian Society of Lubricants of Rades (Multinational company Shell), (Tunisia)
    Role: Internship
    Project: Follow-up of manufacturing processes, packaging and quality control of lubricants and identification and evaluation of chemical risks

    May 2014: Internal audits in laboratory, Delta, Tunis, Tunisia
    Description: 3 days training in how to conduct an internal audit in a laboratory according to the ISO/IEC 17025 standard and treatment of non-conformities and collective action

    May 2014: Technical requirements of the ISO/IEC 17025 standard, Delta, Tunis, Tunisia Description: 3 days training to learn the normative and informative guidelines for testing laboratories accredited to ISO/IEC 17025

  • OUTREACH ACTIVITIES AND RESPONSABILITIES

    - Poster Judge at the Controlled Release Society conference, Las Vegas (July 2023)

    - Reviewer for PhD and Master candidate applications for the Regroupement intersectoriel de recherche en santé de l’Université du Québec (RISUQ) fellowships (since March 2023)

    - Mentor for high school students to popularize science (2021-2022)

    - Mentor for new arriving student to INRS-EMT center (Since August 2020)

    - Member of the « Controlled Release Society » (Since June 2020)

    - Representative of INRS-EMT student in the INRS student Federation FEINRS (Since February 2020)

    - Main organizer of 2 Inter-Center Congress of INRS “Scientific lunches of INRS” (Virtual event- ongoing) and “the Scientific days of INRS (Winter 2021)” (Since January 2020)

    - Ambassador of the « institut National de la Recherche Scientifique (INRS) » (Since June 2019)

    - Main organizer of a molecular cooking workshop in order to popularize science and explain to 170 students the projects we are currently doing in our group, I developed. The success of this workshop has been highlighted also in a brief interview in Radio Canada. (September 2019)

    - Co-organizer of the 50ème anniversaire de l'INRS (September 2019).

    - Co-organizer of Journée « portes ouvertes de l'INRS » (November 2019)

    - Active member of INRS-EMT Student Committee (Since February 2019)

    - Member of the « Canadian Biomaterials Society » (Since February 2019)

    - Co-organizer of Journée d'accueil des étudiants du centre EMT de l’INRS (Since February 2019)

    - Co-organizer of Journée « rendez-vous carrière » (April 2019)

    - Member of the PrEEmiuM, Process Engineering of Emerging Nano-Medicines (http://www.preemium.ca/en/) (Since January 2019).

    - Volunteer for the preparatory workshop of the conference "The Canadian Chapter of the Controlled Release Society (CC-CRS) (May 2018)

    - Member of the « Canadian Chapter of the Controlled Release Society » (Since March 2017)

    - Main organiser of the scientific days "Materials and Environment" organized by

    The Tunisian Chemical Society (Université Libre de Tunis (Avril 2015)

    - Former member of the club of young Tunisian chemists (January 2011- January 2012)

    SUPERVISION EXPERIENCE

    - Nikita Jha: Mitacs internship for master students (Canada 2022)

    - Mikael Marineau: High school student (apprentis chercheurs program-INRS, Canada 2022)

    - Victoria Bloquert: Mitacs internship for master student (Canada 2021)

    - Liu Huining: Student at Marianopolis College (3 days) (Canada 2020)

    - He Jing Yi: Student at Marianopolis College (3 days) (Canada 2020)

    - Syrine Mghirbi: High school student (3 days) (Canada 2020)

    - Nabiha Nahar: High school student (3 days) (Canada 2020)

    - Navid Zuberi: Student at Marianopolis College (3 months) (Canada 2019)

    - Laura Gonza: Student at Marianopolis College (3 days) (Canada 2019)

    - Sarra Bernard: Student saint Hyacinth CEGEP (Canada 2 weeks)

    In the internships of 3 days, I mainly taught the students how to use advanced techniques in our lab (synthesis: PEGylation, analytical: Electrophoresis, HPLC, NTA)